Publications

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Angelakos CC, Girven KS, Liu Y, Gonzalez OC, Murphy KR, Jennings KJ, Giardino WJ, Zweifel LS, Suko A, Palmiter RD, Clark SD, Krasnow MA, Bruchas MR, de Lecea L. A cluster of neuropeptide S neurons regulates breathing and arousal. Curr Biol. 2023 Dec 18;33(24):5439-5455.e7. doi: 10.1016/j.cub.2023.11.018. Epub 2023 Dec 5. PubMed PMID: 38056461; PubMed Central PMCID: PMC10842921.

Huang Y, Wojciechowski A, Feldman K, Ettaro R, Veros K, Ritter M, Carvalho Costa P, DiStasio J, Peirick JJ, Reissner KJ, Runyon SP, Clark SD. RTI-263, a biased neuropeptide S receptor agonist that retains an anxiolytic effect, attenuates cocaine-seeking behavior in rats. Neuropharmacology. 2023 Dec 15;241:109743. doi: 10.1016/j.neuropharm.2023.109743. Epub 2023 Oct 9. PubMed PMID: 37820934.

Park J, Moon JH, O'Shea H, Shin D, Hwang SU, Li L, Lee H, Brimble E, Lee J, Clark S, Lee SK, Jeon S. The patient-specific mouse model with Foxg1 frameshift mutation uncovers the pathophysiology of FOXG1 syndrome. Res Sq. 2023 Jun 2;. doi: 10.21203/rs.3.rs-2953760/v1. PubMed PMID: 37398410; PubMed Central PMCID: PMC10312924.

King G, Veros KM, MacLaren DAA, Leigh MPK, Spernyak JA, Clark SD. Human wildtype tau expression in cholinergic pedunculopontine tegmental neurons is sufficient to produce PSP-like behavioural deficits and neuropathology. Eur J Neurosci. 2021 Nov;54(10):7688-7709. doi: 10.1111/ejn.15496. Epub 2021 Nov 2. PubMed PMID: 34668254; PubMed Central PMCID: PMC9355171.

Zarkin A, Jahan R, Uprety R, Zhang Y, McElhinny C, Snyder R, Gay E, Jewula G, Bool H, Clark SD, Runyon S. Identification of a Novel Neuropeptide S Receptor Antagonist Scaffold Based on the SHA-68 Core. Pharmaceuticals (Basel). 2021 Oct 6;14(10). doi: 10.3390/ph14101024. PubMed PMID: 34681248; PubMed Central PMCID: PMC8538004.

Chambers NE, Coyle M, Sergio J, Lanza K, Saito C, Topping B, Clark SD, Bishop C. Effects of pedunculopontine nucleus cholinergic lesion on gait and dyskinesia in hemiparkinsonian rats. Eur J Neurosci. 2021 Apr;53(8):2835-2847. doi: 10.1111/ejn.15106. Epub 2021 Jan 24. PubMed PMID: 33426708.

Ettaro R, Laudermilk L, Clark SD, Maitra R. Behavioral assessment of rimonabant under acute and chronic conditions. Behav Brain Res. 2020 Jul 15;390:112697. doi: 10.1016/j.bbr.2020.112697. Epub 2020 May 15. PubMed PMID: 32417279; PubMed Central PMCID: PMC7323871.

Ettaro R, Markovic T, Daniels D, MacLaren DA, Clark SD. Microinjection of urotensin II into the pedunculopontine tegmentum leads to an increase in the consumption of sweet tastants. Physiol Behav. 2020 Mar 1;215:112775. doi: 10.1016/j.physbeh.2019.112775. Epub 2019 Dec 13. PubMed PMID: 31843472; PubMed Central PMCID: PMC8691100.

MacLaren DAA, Ljungberg TL, Griffin ME, Clark SD. Pedunculopontine tegmentum cholinergic loss leads to a progressive decline in motor abilities and neuropathological changes resembling progressive supranuclear palsy. Eur J Neurosci. 2018 Dec;48(12):3477-3497. doi: 10.1111/ejn.14212. Epub 2018 Nov 9. PubMed PMID: 30339310.

Clark SD, Kenakin TP, Gertz S, Hassler C, Gay EA, Langston TL, Reinscheid RK, Runyon SP. Identification of the first biased NPS receptor agonist that retains anxiolytic and memory promoting effects with reduced levels of locomotor stimulation. Neuropharmacology. 2017 May 15;118:69-78. doi: 10.1016/j.neuropharm.2017.03.001. Epub 2017 Mar 3. PubMed PMID: 28267583; PubMed Central PMCID: PMC5414581.

MacLaren DA, Browne RW, Shaw JK, Krishnan Radhakrishnan S, Khare P, España RA, Clark SD. Clozapine N-Oxide Administration Produces Behavioral Effects in Long-Evans Rats: Implications for Designing DREADD Experiments. eNeuro. 2016 Sep-Oct;3(5). doi: 10.1523/ENEURO.0219-16.2016. eCollection 2016 Sep-Oct. PubMed PMID: 27822508; PubMed Central PMCID: PMC5089539.

Santollo J, Marshall A, Curtis KS, Speth RC, Clark SD, Daniels D. Divergent effects of ERα and ERβ on fluid intake by female rats are not dependent on concomitant changes in AT1R expression or body weight. Am J Physiol Regul Integr Comp Physiol. 2016 Jul 1;311(1):R14-23. doi: 10.1152/ajpregu.00102.2016. Epub 2016 Apr 27. PubMed PMID: 27122368; PubMed Central PMCID: PMC4967226.

Bensaid M, Michel PP, Clark SD, Hirsch EC, François C. Role of pedunculopontine cholinergic neurons in the vulnerability of nigral dopaminergic neurons in Parkinson's disease. Exp Neurol. 2016 Jan;275 Pt 1:209-19. doi: 10.1016/j.expneurol.2015.11.004. Epub 2015 Nov 10. PubMed PMID: 26571193.

Bensaid M, Michel PP, Clark SD, Hirsch EC, François C. Role of pedunculopontine cholinergic neurons in the vulnerability of nigral dopaminergic neurons in Parkinson's disease. Exp Neurol. 2016 Jan;275 Pt 1:209-19. doi: 10.1016/j.expneurol.2015.11.004. Epub 2015 Nov 10. PubMed PMID: 26571193.

Likhite N, Jackson CA, Liang MS, Krzyzanowski MC, Lei P, Wood JF, Birkaya B, Michaels KL, Andreadis ST, Clark SD, Yu MC, Ferkey DM. The protein arginine methyltransferase PRMT5 promotes D2-like dopamine receptor signaling. Sci Signal. 2015 Nov 10;8(402):ra115. doi: 10.1126/scisignal.aad0872. PubMed PMID: 26554819; PubMed Central PMCID: PMC5473623.

Mueller LE, Kausch MA, Markovic T, MacLaren DA, Dietz DM, Park J, Clark SD. Intra-ventral tegmental area microinjections of urotensin II modulate the effects of cocaine. Behav Brain Res. 2015 Feb 1;278:271-9. doi: 10.1016/j.bbr.2014.09.036. Epub 2014 Oct 1. PubMed PMID: 25264578; PubMed Central PMCID: PMC4382453.

Cyr M, Parent MJ, Mechawar N, Rosa-Neto P, Soucy JP, Clark SD, Aghourian M, Bedard MA. Deficit in sustained attention following selective cholinergic lesion of the pedunculopontine tegmental nucleus in rat, as measured with both post-mortem immunocytochemistry and in vivo PET imaging with [¹⁸F]fluoroethoxybenzovesamicol. Behav Brain Res. 2015 Feb 1;278:107-14. doi: 10.1016/j.bbr.2014.09.021. Epub 2014 Sep 22. PubMed PMID: 25257103.

MacLaren DAA, Markovic T, Daniels D, Clark SD. Enhanced consumption of salient solutions following pedunculopontine tegmental lesions. Neuroscience. 2015 Jan 22;284:381-399. doi: 10.1016/j.neuroscience.2014.09.075. Epub 2014 Oct 8. PubMed PMID: 25305665; PubMed Central PMCID: PMC4268404.

Santollo J, Whalen PE, Speth RC, Clark SD, Daniels D. Properly timed exposure to central ANG II prevents behavioral sensitization and changes in angiotensin receptor expression. Am J Physiol Regul Integr Comp Physiol. 2014 Dec 15;307(12):R1396-404. doi: 10.1152/ajpregu.00373.2014. Epub 2014 Oct 29. PubMed PMID: 25354729; PubMed Central PMCID: PMC4269669.

MacLaren DA, Markovic T, Clark SD. Assessment of sensorimotor gating following selective lesions of cholinergic pedunculopontine neurons. Eur J Neurosci. 2014 Nov;40(10):3526-37. doi: 10.1111/ejn.12716. Epub 2014 Sep 11. PubMed PMID: 25208852.

MacLaren DA, Santini JA, Russell AL, Markovic T, Clark SD. Deficits in motor performance after pedunculopontine lesions in rats--impairment depends on demands of task. Eur J Neurosci. 2014 Oct;40(8):3224-36. doi: 10.1111/ejn.12666. Epub 2014 Jul 4. PubMed PMID: 24995993.

Belaid H, Adrien J, Laffrat E, Tandé D, Karachi C, Grabli D, Arnulf I, Clark SD, Drouot X, Hirsch EC, François C. Sleep disorders in Parkinsonian macaques: effects of L-dopa treatment and pedunculopontine nucleus lesion. J Neurosci. 2014 Jul 2;34(27):9124-33. doi: 10.1523/JNEUROSCI.0181-14.2014. PubMed PMID: 24990932; PubMed Central PMCID: PMC4078088.

Cyr M, Parent MJ, Mechawar N, Rosa-Neto P, Soucy JP, Aliaga A, Kostikov A, Maclaren DA, Clark SD, Bedard MA. PET imaging with [¹⁸F]fluoroethoxybenzovesamicol ([¹⁸F]FEOBV) following selective lesion of cholinergic pedunculopontine tegmental neurons in rat. Nucl Med Biol. 2014 Jan;41(1):96-101. doi: 10.1016/j.nucmedbio.2013.10.004. Epub 2013 Oct 21. PubMed PMID: 24267056.

Gancarz-Kausch AM, Schroeder GL, Panganiban C, Adank D, Humby MS, Kausch MA, Clark SD, Dietz DM. Transforming growth factor beta receptor 1 is increased following abstinence from cocaine self-administration, but not cocaine sensitization. PLoS One. 2013;8(12):e83834. doi: 10.1371/journal.pone.0083834. eCollection 2013. PubMed PMID: 24386286; PubMed Central PMCID: PMC3875479.

Clark SD, Duangdao DM, Schulz S, Zhang L, Liu X, Xu YL, Reinscheid RK. Anatomical characterization of the neuropeptide S system in the mouse brain by in situ hybridization and immunohistochemistry. J Comp Neurol. 2011 Jul 1;519(10):1867-93. doi: 10.1002/cne.22606. PubMed PMID: 21452235.

Okamura N, Garau C, Duangdao DM, Clark SD, Jüngling K, Pape HC, Reinscheid RK. Neuropeptide S enhances memory during the consolidation phase and interacts with noradrenergic systems in the brain. Neuropsychopharmacology. 2011 Mar;36(4):744-52. doi: 10.1038/npp.2010.207. Epub 2010 Dec 8. PubMed PMID: 21150909; PubMed Central PMCID: PMC3037424.

Si W, Aluisio L, Okamura N, Clark SD, Fraser I, Sutton SW, Bonaventure P, Reinscheid RK. Neuropeptide S stimulates dopaminergic neurotransmission in the medial prefrontal cortex. J Neurochem. 2010 Oct;115(2):475-82. doi: 10.1111/j.1471-4159.2010.06947.x. Epub 2010 Aug 30. PubMed PMID: 20722970; PubMed Central PMCID: PMC2970681.

Gill RS, Hsiung MS, Sum CS, Lavine N, Clark SD, Van Tol HH. The dopamine D4 receptor activates intracellular platelet-derived growth factor receptor beta to stimulate ERK1/2. Cell Signal. 2010 Feb;22(2):285-90. doi: 10.1016/j.cellsig.2009.09.031. Epub 2009 Sep 24. PubMed PMID: 19782129.

Clark SD, Tran HT, Zeng J, Reinscheid RK. Importance of extracellular loop one of the neuropeptide S receptor for biogenesis and function. Peptides. 2010 Jan;31(1):130-8. doi: 10.1016/j.peptides.2009.10.015. Epub 2009 Oct 27. PubMed PMID: 19874863; PubMed Central PMCID: PMC2814945.

Duangdao DM, Clark SD, Okamura N, Reinscheid RK. Behavioral phenotyping of neuropeptide S receptor knockout mice. Behav Brain Res. 2009 Dec 14;205(1):1-9. doi: 10.1016/j.bbr.2009.07.024. Epub 2009 Jul 29. PubMed PMID: 19646487; PubMed Central PMCID: PMC2753742.

Nagasaki H, Chung S, Dooley CT, Wang Z, Li C, Saito Y, Clark SD, Houghten RA, Civelli O. The pharmacological properties of a novel MCH1 receptor antagonist isolated from combinatorial libraries. Eur J Pharmacol. 2009 Jan 14;602(2-3):194-202. doi: 10.1016/j.ejphar.2008.10.068. Epub 2008 Nov 17. PubMed PMID: 19041642; PubMed Central PMCID: PMC2633472.

Jüngling K, Seidenbecher T, Sosulina L, Lesting J, Sangha S, Clark SD, Okamura N, Duangdao DM, Xu YL, Reinscheid RK, Pape HC. Neuropeptide S-mediated control of fear expression and extinction: role of intercalated GABAergic neurons in the amygdala. Neuron. 2008 Jul 31;59(2):298-310. doi: 10.1016/j.neuron.2008.07.002. PubMed PMID: 18667157; PubMed Central PMCID: PMC2610688.

Clark SD, Alderson HL, Winn P, Latimer MP, Nothacker HP, Civelli O. Fusion of diphtheria toxin and urotensin II produces a neurotoxin selective for cholinergic neurons in the rat mesopontine tegmentum. J Neurochem. 2007 Jul;102(1):112-20. doi: 10.1111/j.1471-4159.2007.04529.x. Epub 2007 Apr 10. PubMed PMID: 17419804.

Clark SD, Nothacker HP, Blaha CD, Tyler CJ, Duangdao DM, Grupke SL, Helton DR, Leonard CS, Civelli O. Urotensin II acts as a modulator of mesopontine cholinergic neurons. Brain Res. 2005 Oct 19;1059(2):139-48. doi: 10.1016/j.brainres.2005.08.026. Epub 2005 Sep 23. PubMed PMID: 16183039.

Huitron-Resendiz S, Kristensen MP, Sánchez-Alavez M, Clark SD, Grupke SL, Tyler C, Suzuki C, Nothacker HP, Civelli O, Criado JR, Henriksen SJ, Leonard CS, de Lecea L. Urotensin II modulates rapid eye movement sleep through activation of brainstem cholinergic neurons. J Neurosci. 2005 Jun 8;25(23):5465-74. doi: 10.1523/JNEUROSCI.4501-04.2005. PubMed PMID: 15944374; PubMed Central PMCID: PMC6724976.

Van Craenenbroeck K, Clark SD, Cox MJ, Oak JN, Liu F, Van Tol HH. Folding efficiency is rate-limiting in dopamine D4 receptor biogenesis. J Biol Chem. 2005 May 13;280(19):19350-7. doi: 10.1074/jbc.M414043200. Epub 2005 Mar 8. PubMed PMID: 15755724.

Xu YL, Reinscheid RK, Huitron-Resendiz S, Clark SD, Wang Z, Lin SH, Brucher FA, Zeng J, Ly NK, Henriksen SJ, de Lecea L, Civelli O. Neuropeptide S: a neuropeptide promoting arousal and anxiolytic-like effects. Neuron. 2004 Aug 19;43(4):487-97. doi: 10.1016/j.neuron.2004.08.005. PubMed PMID: 15312648.

Clark SD, Nothacker HP, Wang Z, Saito Y, Leslie FM, Civelli O. The urotensin II receptor is expressed in the cholinergic mesopontine tegmentum of the rat. Brain Res. 2001 Dec 27;923(1-2):120-7. doi: 10.1016/s0006-8993(01)03208-5. PubMed PMID: 11743979.